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Home Applications Biopharmaceutical Manufacturing Monoclonal Antibody Virus Removal

Virus removal is necessary to reduce virus level in downstream processes of biopharmaceutical manufacturing. According to relevant regulations and guidelines, the design and implementation of virus clearance research in the same production process require different virus inactivation or removal methods to ensure that biological products do not carry any potential risk of virus contamination.


Common virus removal strategies:

  • Virus inactivation
  • Chromatography
  • Membrane filtration


In the downstream process of monoclonal antibody (mAb) production, there is often a potential risk of viral contamination. Virus removal filtration, as the most robust virus removal process, has been widely used in downstream purification processes of blood products such as coagulation factors, immunoglobulins, and recombinant proteins, antibody based biological products.


Cobetter have launched brand new VirucLear VF Plus virus removal filter with composite PES membrane, which increases filtration capacity and has robust virus removal ability.


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