DLHPVDF/LHPVDF Sterilizing-Grade Liquid Filter
Description
Features
- Very low protein adsorption properties
- Good corrosion, oxidation and heat resistance
- Low leachables
- Good chemical compatibility
- 100% integrity testing to ensure sterilization performance
Applications
- Blood products filtration
- Culture media filtration
- Antibiotic sterile filtration
- Biological reagents filtration
- Vaccine filtration
Quality
- 100% Integrity testing in manufacturing
- Each filter is fully traceable with unique serial number
- Manufactured in a facility which adheres to ISO 9001:2015 Practices
Flow Rate Characteristics

Specifications
Materials of Construction
Membrane | Hydrophilic polyvinylidene fluoride (PVDF) |
Support | Polypropylene (PP) |
Core/Cage/End Caps | Polypropylene (PP) |
End Cap Inserts | Polybutylene terephthalate (PBT) |
Seal Material | Silicone / EPDM / Viton FEP/ PFA encapsulated O-rings |
Operating Conditions
Max. Operating Temperature |
80°C |
Max.Operating Pressure |
0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C |
Max. Differential Pressure (Forward) |
0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C |
Max. Differential Pressure (Reverse) |
0.30 MPa@25°C 0.10 MPa@80°C |
Filtration Area
Outer Diameter | Membrane Pore Size | Area/10" | |
DLHPVDF | 69 mm | 0.22+0.1 μm | 0.55 m2 |
69 mm | 0.22+0.22 μm | 0.55 m2 | |
69 mm | 0.45+0.22 μm | 0.55 m2 | |
69 mm | 0.45+0.45 μm | 0.58 m2 | |
69 mm | 0.65+0.45 μm | 0.58 m2 | |
LHPVDF | 69 mm | 0.1 μm | 0.58 m2 |
69 mm | 0.22 μm | 0.58 m2 | |
69 mm | 0.45 μm | 0.58 m2 | |
69 mm | 0.65 μm | 0.58 m2 |
Integrity Test Standards @10inch,20°C (DLHPVDF)
Membrane Pore Size | Bubble Point | Air Diffusion |
0.22+0.22 μm | ≥ 0.32 MPa (water), Air Testing | ≤ 16 ml/min @ 0.28 MPa (water) |
0.45+0.22 μm | ≥ 0.32 MPa (water), Air Testing | ≤ 20 ml/min @ 0.28 MPa (water) |
0.45+0.45 μm | ≥ 0.16 MPa (water), Air Testing | |
0.65+0.45 μm | ≥ 0.12 MPa (water), Air Testing | ≤ 10 ml/min @ 0.1 MPa (water) |
Integrity Test Standards @10inch,20°C (LHPVDF)
Membrane Pore Size | Bubble Point | Air Diffusion |
0.1 μm | ≥ 0.16 MPa,Wetted with 60% IPA, Air Test | ≤ 30 ml/min @ 0.386 MPa,Water Wetting |
0.22 μm | ≥ 0.32 MPa,Water wetting, Air Testing | ≤ 20 ml/min @ 0.28 MPa,Water Wetting |
0.45 μm | ≥ 0.12 MPa,Water wetting, Air Testing | ≤ 10 ml/min @ 0.10 MPa,Water Wetting |
0.65 μm | ≥ 0.10 MPa,Water Wetting, Air Testing |
Bacterial Retention
Model | Content |
DLHPVDF 0.22+0.22 μm | Bacterial quantitative retention of 10? cfu/cm2 Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology. |
DLHPVDF 0.45+0.22μm | |
DLHPVDF 0.45+0.45 μm | Bacterial quantitative retention of 10? cfu/cm2 Serratia marcescens (ATCC14756) according to ASTM F838 methodology. |
DLHPVDF 0.65+0.45 μm | |
LHPVDF 0.1μm | Bacterial quantitative retention of 10? cfu/cm2 Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology. |
LHPVDF 0.22μm | |
LHPVDF 0.45 μm | Bacterial quantitative retention of 10? cfu/cm2 Serratia marcescens (ATCC14756) according to ASTM F838 methodology. |
Sterilization
In-line steam sterilization | Up to 50 cycles (135°C for 30 min and differential pressure < 30 kPa per cycle) |
Autoclave | Up to 50 cycles (130°C for 30 min per cycle) |
Regulatory Compliance
- Autoclaved filter effluent meets the USP<788> requirement of particulate matter in large volume injection.
- Component materials meet the criteria for a "Non-fiber-releasing filter" as defined in 21 CFR 210.3(b)(6).
- Aqueous extraction from a cartridge contains less than 0.25EU/ml as determined by Limulus Amebocyte Lysate (LAL), meeting requirements of USP<85>.
- Meet the requirement of USP <87> In Vitro Cytotoxicity Test.
- Component materials meet the requirements of the current USP<88> for plastic class VI-121°C.
- All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177-182.
- Based on the current information from our suppliers, all component materials used in the manufacture of this product are animal-free.
End Cap

Ordering Information
DLHPVDF (Double-layer)
Outer Diameter | Type | Membrane Pore Size | End Cap | Nominal Length | Seal Material | Industry |
69mm | DLHPVDF | 2210 0.22+0.1μm | DOE Double Open End | 05 5 inch | S Silicone | P |
2222 0.22+0.22μm | HTF 222/Fin (PBT insert) | 10 10 inch | E EPDM | |||
4522 0.45+0.22μm | HSF 226/Fin (PBT insert) | 20 20 inch | V Viton | |||
4545 0.45+0.45μm | HTCG 222/Flat (PBT insert) | 30 30 inch | P FEP/PFA encapsulated O-rings | |||
6545 0.65+0.45μm | HSCG 226/Flat (PBT insert) | 40 40 inch |
LHPVDF (Single-layer)
Outer Diameter | Type | Membrane Pore Size | End Cap | Nominal Length | Seal Material | Industry |
69mm | LHPVDF | 0010 0.1μm | DOE Double Open End | 05 5 inch | S Silicone | P |
0022 0.22μm | HTF 222/Fin (PBT insert) | 10 10 inch | E EPDM | |||
0045 0.45μm | HSF 226/Fin (PBT insert) | 20 20 inch | V Viton | |||
0065 0.65μm | HTCG 222/Flat (PBT insert) | 30 30 inch | P FEP/PFA encapsulated O-rings | |||
HSCG 226/Flat (PBT insert) | 40 40 inch |
* Example:DLHPVDF2210DOE05SP (DLHPVDF,0.22+0.1μm,Double open end,5 inch,Silicone,Pharmaceutical)