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Home Applications Cell and Gene Therapy Gene Therapy Polishing

Downstream purification in biopharmaceutical production involves multiple chromatography steps for protein purification and removing impurities. Chromatography is one of the core technologies in the purification process of monoclonal antibody products, mainly aimed at removing host cell DNA, host proteins, and related impurities. Chromatography can be divided into affinity chromatography, ion exchange chromatography, hydrophobic chromatography, and molecular sieve chromatography based on their principles.


Ion exchange chromatography has been widely used in the separation and purification of various biomolecules such as antibodies, peptides, sugars, nucleic acids, viruses, etc. In the downstream polishing purification of monoclonal antibodies, anion membrane chromatography can balance process efficiency and impurity removal. In the fields of vaccines, gene and cell therapy, and mRNA industry, anion membrane chromatography not only has high adsorption capacity but also better separation efficiency for the purification of lentiviral vectors, adenovirus vectors, and plasmids.


With our unique expertise in membrane manufacturing, Cobetter have developed Purcise? Q membrane chromatography aimed to enhance process efficiency and reduce development costs in downstream processes.

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