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APSNDB Sterilizing-Grade Liquid Filter

Very low adsorption using a single-layer hydrophilic asymmetric polyethersulfone membrane

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Description Specifications Ordering Information

Description

Features

Hydrophilic polyethersulfone membranes offer very low adsorption and broad chemical compatibility
Asymmetric membranes for higher loading capacity and lower costs
Sterilization for simple solvents, effective bacterial reduction for some complex fluid applications

Applications

Buffer sterile filtration

Quality

100% Integrity testing in manufacturing
Each filter is fully traceable with unique serial number
Manufactured in a facility which adheres to ISO 9001:2015 Practices

Flow Rate Characteristics

Specifications

Materials of Construction

Membrane	Hydrophilic polyethersulfone (PES)
Support	Polypropylene (PP)
Core/Cage/End Caps	Polypropylene (PP)
End Cap Inserts	Polybutylene terephthalate (PBT)
Seal Material	Silicone / EPDM / Viton FEP/ PFA encapsulated O-rings

Operating Conditions

Max. Operating Temperature	80°C
Max.Operating Pressure	0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C
Max. Differential Pressure (Forward)	0.69 MPa@25°C 0.40 MPa@60°C 0.24 MPa@80°C
Max. Differential Pressure (Reverse)	0.30 MPa@25°C 0.10 MPa@80°C

Filtration Area

Outer Diameter	Membrane Pore Size	Area/10"
69mm	0.22μm	0.55m2

Integrity Standard @10inch，20°C

Membrane Pore Size	Bubble Point
0.22μm	≥ 0.32 MPa (water), Air test

Bacterial Retention

Model	Content
APSNDB 0.22μm	Bacterial quantitative retention of 10? cfu/cm2 Brevundimonas diminuta (ATCC 19146) accordingto ASTM F838 methodology.

Sterilization

In-line steam sterilization

Up to 30 cycles (135 °C for 30 min and differential pressure < 30 kPa per cycle)

Regulatory Compliance

Autoclaved filter effluent meets the USP<788> requirement of particulate matter in large volume injection.
Component materials meet the criteria for a "Non-fiber-releasing filter" as defined in 21 CFR 210.3(b)(6).
Aqueous extraction from a cartridge contains less than 0.25EU/ml as determined by Limulus Amebocyte Lysate (LAL), meeting requirements of USP<85>.
Meet the requirement of USP <87> In Vitro Cytotoxicity Test.
Component materials meet the requirements of the current USP<88> for plastic class VI-121°C.
All component materials meet the FDA Indirect Food Additive requirements cited in 21 CFR 177-182.
Based on the current information from our suppliers, all component materials used in the manufacture of this product are animal-free.

End Cap

Ordering Information

Outer Diameter	Type	Membrane Pore Size	End Cap	Nominal Length	Seal Material	Industry
69mm	APSNDB	0022 0.22μm	DOE Double Open End	05 5 inch	S Silicone	P
			HTF 222/Fin	10 10 inch	E EPDM
			HSF 226/Fin	20 20 inch	V Viton
			HTCG 222/Flat	30 30 inch	P FEP/PFA encapsulated O-rings
			HSCG 226/Flat	40 40 inch

* Example：APSNDB0022DOE05SP (DPSHSL，0.22+0.1μm，Double Open End，5 inch，Silicone，Pharmaceutical)

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